![]() In addition to the central clock, peripheral tissues (lung, liver and heart) also contain autonomous circadian oscillators that regulate cellular functions and responses to environmental exposure. A central pacemaker located in the anterior suprachiasmatic nucleus (SCN) of the hypothalamus, controls the rhythms of behavior and physiology and synchronizes internal time with the external environment in mammals. The biological clock is a 24-hour internal timekeeping system that affects the rhythms of body’s behavior, physiology, and gene expression. Therefore, new perceptions into the pathogenesis of COPD are required. The pathogenesis of COPD is still remain unclear, and the main treatment method is to improve the symptoms of COPD patients, but it cannot delay disease progression and reduce mortality. The incidence of COPD was five-fold higher in people aged 65 years than in people aged less than 40 years. Humans will live longer by 2050, 21% of the world’s population will be 60 years or older and the incidence of age-related chronic diseases is also increasing, such as COPD. Therefore, our findings indicated that Bmal1 or Clock deficiency may be a significant factor to increase cellular senescence of the lung to develop COPD.Ĭhronic obstructive pulmonary disease (COPD) is a progressive respiratory disease and is considered to be the most important respiratory disease worldwide. We found that knockdown of Clock or Bmal1 lead to upregulation of cell senescence in Beas-2B cells, while overexpression of Clock or Bmal1 inhibited cell senescence in Beas-2B cells, which is through the MAPK pathways. Interestingly, CSE exposure contributed to the increased cell senescence, decreased Clock and Bmal1 in human bronchial epithelial cells (Beas-2B cells). Herein, patients with COPD showed lower Bmal1 and Clock expression in the plasma. ![]() The regulation of ciracadian clock expression and cell senescence by cigarette smoke extract (CSE) was studied in vitro, and small interfering RNA (siRNA) and overexpression of Bmal1 or Clock were employed to investigate the role of circadian clock on cell senescence. Bmal1 and Clock levels were assessed in the plasma samples of non-smokers, smokers, and patients with COPD. The aim of this study is to investigate the role of the circadian clock protein BMAL1 and CLOCK in cellular senescence in order to understand the cellular mechanisms of accelerated aging of COPD. Although the circadian molecular clock regulates cellular senescence, there is no information available regarding the impact of COPD. Circadian clock is believed to play important roles in COPD. COPD is associated with accelerated lung aging. ![]() Chronic obstructive pulmonary disease (COPD) is a progressive respiratory disease. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |